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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
T64320 | ML251 | Glucokinase , Parasite | |
ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]... | |||
T10339 | Antitrypanosomal agent 1 | Parasite | |
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM). Antitrypanosomal agent 1 inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM). | |||
T63610 | SPR7 | ||
SPR7 is a potent and selective rhodesain inhibitor (Ki: 0.51 nM). SPR7 exhibited antiparasitic effects against T. b. brucei (EC50: 1.65 μM). | |||
T79568 | NPD-2975 | Parasite | |
NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibrobl... | |||
T72267 | Antitrypanosomal agent 9 | ||
Antitrypanosomal agent 9 is a potent compound with inhibitory activity against T. b. brucei, exhibiting an IC50 of 1.15 μM. It is utilized in research for human African trypanosomiasis (HAT). | |||
T14115 | Acoziborole | SCYX-7158,AN5568 | Others |
Acoziborole (SCYX-7158), a derivative of benzoxaborole, is a safe, effective and structurally novel antigen-worm agent for human African trypanosomiasis (HAT) studies. The MIC value of Acoziborole for T. b. brucei S427 w... | |||
T75617 | Salviandulin E | ||
Salviandulin E, a diterpenoid isolated from Salvia leucantha CAV., exhibits antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites, demonstrating an IC50 value of 0.72 µg/mL [1] [2]. | |||
T62212 | Antitrypanosomal agent 4 | ||
Antitrypanosomal agent 4 (compound 19) is a potent antitrypanosomal agent that crosses the blood-brain barrier and shows good resistance to Trypanosoma cruzi and T. b. brucei with IC50 values of 1.2 μM and 70 nM respecti... | |||
T81503 | PEX5-PEX14 PPI-IN-2 | ||
Compound 12, also known as PEX5-PEX14 PPI-IN-2, is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor with half-maximal effective concentration (EC50) values of 5 µM in T. b. brucei and 17 µM in HepG2 cells. It is ... | |||
T62255 | 20S Proteasome-IN-4 | ||
20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag... | |||
T38243 | Hygrolidin | ||
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC... | |||
T79457 | PEX5-PEX14 PPI-IN-1 | ||
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the b... | |||
T11711 | Jaspamycin | 7-CN-7-C-Ino | JAK |
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in T... | |||
T13223 | Tuberculosis inhibitor 1 | Others | |
Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM). |